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555: Symmetric Beta Core Design Puzzle 1

Closed since almost 14 years ago

Intermediate Intermediate Overall Overall Design Design Symmetry Symmetry

Summary

Created
May 09, 2012
Expires
Max points
100
Description

The ...WXCXW... motif adopts a remarkably stable homodimer structure. In fact, it's so tiny, it is difficult to use as a building block for bioengineering; it needs to be larger but retain rigidity. Otherwise anything goes: beta sheets, alpha helix docking, rigid loops, you name it. We've given you 20 extra residues to play with. See what you can do! (Hint: select some residues, set secondary structure to sheet or helix, and hit Rebuild for some quick helices or sheets)

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Comments

beta_helix Staff Lv 1

Because we want to preserve the frozen sheets and disulfide bond across the symmetric interface, we had to turn off the move tool and lock residue 7 as well.