Placeholder image of a protein
Icon representing a puzzle

555: Symmetric Beta Core Design Puzzle 1

Closed since almost 14 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 09, 2012
Expires
Max points
100
Description

The ...WXCXW... motif adopts a remarkably stable homodimer structure. In fact, it's so tiny, it is difficult to use as a building block for bioengineering; it needs to be larger but retain rigidity. Otherwise anything goes: beta sheets, alpha helix docking, rigid loops, you name it. We've given you 20 extra residues to play with. See what you can do! (Hint: select some residues, set secondary structure to sheet or helix, and hit Rebuild for some quick helices or sheets)

Top groups

  1. Avatar for HMT heritage 11. HMT heritage 10 pts. 9,483
  2. Avatar for Richard Dawkins Foundation 12. Richard Dawkins Foundation 8 pts. 9,452
  3. Avatar for Androids 13. Androids 6 pts. 9,432
  4. Avatar for Russian team 14. Russian team 4 pts. 9,423
  5. Avatar for Deleted group 15. Deleted group pts. 9,304
  6. Avatar for Freedom Folders 16. Freedom Folders 2 pts. 9,198
  7. Avatar for Eὕρηκα! Heureka! 17. Eὕρηκα! Heureka! 2 pts. 9,084
  8. Avatar for Piratenpartei Deutschland 18. Piratenpartei Deutschland 1 pt. 8,950
  9. Avatar for Deleted group 19. Deleted group pts. 8,933
  10. Avatar for Atlanta 20. Atlanta 1 pt. 8,927
  1. Avatar for vote_for100 291. vote_for100 Lv 1 1 pt. 8,430
  2. Avatar for arshak cherkezyan 292. arshak cherkezyan Lv 1 1 pt. 8,430
  3. Avatar for gotdamepupu 293. gotdamepupu Lv 1 1 pt. 8,430
  4. Avatar for georged 294. georged Lv 1 1 pt. 8,430
  5. Avatar for Susume 295. Susume Lv 1 1 pt. 8,430
  6. Avatar for ingoneato 296. ingoneato Lv 1 1 pt. 8,430
  7. Avatar for d41337b3457 297. d41337b3457 Lv 1 1 pt. 8,430
  8. Avatar for drmaybe 298. drmaybe Lv 1 1 pt. 8,430
  9. Avatar for Gerhk 299. Gerhk Lv 1 1 pt. 8,430
  10. Avatar for Radagast 300. Radagast Lv 1 1 pt. 8,430

Comments

beta_helix Staff Lv 1

Because we want to preserve the frozen sheets and disulfide bond across the symmetric interface, we had to turn off the move tool and lock residue 7 as well.