Placeholder image of a protein
Icon representing a puzzle

555: Symmetric Beta Core Design Puzzle 1

Closed since almost 14 years ago

Intermediate Overall Design Symmetry

Summary

Created
May 09, 2012
Expires
Max points
100
Description

The ...WXCXW... motif adopts a remarkably stable homodimer structure. In fact, it's so tiny, it is difficult to use as a building block for bioengineering; it needs to be larger but retain rigidity. Otherwise anything goes: beta sheets, alpha helix docking, rigid loops, you name it. We've given you 20 extra residues to play with. See what you can do! (Hint: select some residues, set secondary structure to sheet or helix, and hit Rebuild for some quick helices or sheets)

Top groups

  1. Avatar for Koronan ChemistryUO Poland 21. Koronan ChemistryUO Poland 1 pt. 8,924
  2. Avatar for Nerdfighters 22. Nerdfighters 1 pt. 8,922
  3. Avatar for Czech National Team 23. Czech National Team 1 pt. 8,869
  4. Avatar for DSN @ Home 24. DSN @ Home 1 pt. 8,854
  5. Avatar for Trinity 25. Trinity 1 pt. 8,850
  6. Avatar for Team China 26. Team China 1 pt. 8,845
  7. Avatar for Friday Lab 27. Friday Lab 1 pt. 8,845
  8. Avatar for Skeptics Guide to the Universe 28. Skeptics Guide to the Universe 1 pt. 8,839
  1. Avatar for spmm 11. spmm Lv 1 85 pts. 9,678
  2. Avatar for TheGUmmer 12. TheGUmmer Lv 1 83 pts. 9,671
  3. Avatar for steveB 13. steveB Lv 1 82 pts. 9,661
  4. Avatar for cbwest 14. cbwest Lv 1 81 pts. 9,654
  5. Avatar for Flagg65a 15. Flagg65a Lv 1 79 pts. 9,649
  6. Avatar for Judecca 16. Judecca Lv 1 78 pts. 9,647
  7. Avatar for micheldeweerd 17. micheldeweerd Lv 1 76 pts. 9,643
  8. Avatar for pauldunn 18. pauldunn Lv 1 75 pts. 9,635
  9. Avatar for martinzblavy 19. martinzblavy Lv 1 74 pts. 9,633
  10. Avatar for dembones 20. dembones Lv 1 73 pts. 9,630

Comments

beta_helix Staff Lv 1

Because we want to preserve the frozen sheets and disulfide bond across the symmetric interface, we had to turn off the move tool and lock residue 7 as well.