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571: Tissue Regeneration Design Puzzle

Closed since almost 14 years ago

Beginner Overall Design

Summary

Created
June 07, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.

Top groups

  1. Avatar for Gargleblasters 11. Gargleblasters 13 pts. 9,508
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  3. Avatar for Piratenpartei Deutschland 13. Piratenpartei Deutschland 7 pts. 9,501
  4. Avatar for 7Monkeys 14. 7Monkeys 6 pts. 9,490
  5. Avatar for SETI.Germany 15. SETI.Germany 4 pts. 9,490
  6. Avatar for Deleted group 16. Deleted group pts. 9,486
  7. Avatar for BOINC@Poland 17. BOINC@Poland 2 pts. 9,480
  8. Avatar for Freedom Folders 18. Freedom Folders 2 pts. 9,479
  9. Avatar for Team Canada 19. Team Canada 1 pt. 9,475
  10. Avatar for Aperture Science 20. Aperture Science 1 pt. 9,475
  1. Avatar for Sadler 121. Sadler Lv 1 12 pts. 9,490
  2. Avatar for Bautho 122. Bautho Lv 1 12 pts. 9,490
  3. Avatar for Schleicher 123. Schleicher Lv 1 12 pts. 9,489
  4. Avatar for kdieber 124. kdieber Lv 1 11 pts. 9,489
  5. Avatar for Brewster 125. Brewster Lv 1 11 pts. 9,489
  6. Avatar for concoxide 126. concoxide Lv 1 11 pts. 9,488
  7. Avatar for blob_folder 127. blob_folder Lv 1 11 pts. 9,488
  8. Avatar for CharlieFortsConscience 128. CharlieFortsConscience Lv 1 10 pts. 9,488
  9. Avatar for scottyler89 129. scottyler89 Lv 1 10 pts. 9,486
  10. Avatar for GracielaW 130. GracielaW Lv 1 10 pts. 9,486

Comments

mottiger Lv 1

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

BootsMcGraw Lv 1

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.