Placeholder image of a protein
Icon representing a puzzle

571: Tissue Regeneration Design Puzzle

Closed since almost 14 years ago

Beginner Overall Design

Summary

Created
June 07, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.

Top groups

  1. Avatar for Gargleblasters 11. Gargleblasters 13 pts. 9,508
  2. Avatar for Russian team 12. Russian team 10 pts. 9,504
  3. Avatar for Piratenpartei Deutschland 13. Piratenpartei Deutschland 7 pts. 9,501
  4. Avatar for 7Monkeys 14. 7Monkeys 6 pts. 9,490
  5. Avatar for SETI.Germany 15. SETI.Germany 4 pts. 9,490
  6. Avatar for Deleted group 16. Deleted group pts. 9,486
  7. Avatar for BOINC@Poland 17. BOINC@Poland 2 pts. 9,480
  8. Avatar for Freedom Folders 18. Freedom Folders 2 pts. 9,479
  9. Avatar for Team Canada 19. Team Canada 1 pt. 9,475
  10. Avatar for Aperture Science 20. Aperture Science 1 pt. 9,475
  1. Avatar for rsosborne 31. rsosborne Lv 1 64 pts. 9,535
  2. Avatar for mbinfield 32. mbinfield Lv 1 63 pts. 9,535
  3. Avatar for Galaxie 33. Galaxie Lv 1 62 pts. 9,534
  4. Avatar for spdenne 34. spdenne Lv 1 61 pts. 9,533
  5. Avatar for pauldunn 35. pauldunn Lv 1 60 pts. 9,532
  6. Avatar for gmn 36. gmn Lv 1 59 pts. 9,531
  7. Avatar for spmm 37. spmm Lv 1 58 pts. 9,531
  8. Avatar for Steven Pletsch 38. Steven Pletsch Lv 1 57 pts. 9,531
  9. Avatar for malthreSC 39. malthreSC Lv 1 56 pts. 9,529
  10. Avatar for brow42 40. brow42 Lv 1 55 pts. 9,529

Comments

mottiger Lv 1

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

BootsMcGraw Lv 1

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.