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571: Tissue Regeneration Design Puzzle

Closed since almost 14 years ago

Beginner Overall Design

Summary

Created
June 07, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.

Top groups

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    1. smilingone Lv 1
    100 pts. 9,570
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  7. Avatar for packer 7. packer Lv 1 15 pts. 9,563
  8. Avatar for mbinfield 8. mbinfield Lv 1 11 pts. 9,562
  9. Avatar for mimi 9. mimi Lv 1 7 pts. 9,557
  10. Avatar for Bletchley Park 10. Bletchley Park Lv 1 5 pts. 9,557

Comments

mottiger Lv 1

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

BootsMcGraw Lv 1

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.