Placeholder image of a protein
Icon representing a puzzle

571: Tissue Regeneration Design Puzzle

Closed since almost 14 years ago

Beginner Overall Design

Summary

Created
June 07, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. Read the new blogpost for more details.

Top groups

  1. Avatar for Czech National Team 21. Czech National Team 1 pt. 9,473
  2. Avatar for Geekdo 22. Geekdo 1 pt. 9,472
  3. Avatar for Nerdfighters 23. Nerdfighters 1 pt. 9,459
  4. Avatar for Folding on Linux 24. Folding on Linux 1 pt. 9,443
  5. Avatar for Biology-4th 25. Biology-4th 1 pt. 9,443
  6. Avatar for Atlanta 26. Atlanta 1 pt. 9,430
  7. Avatar for Team China 27. Team China 1 pt. 9,403
  8. Avatar for Skeptics Guide to the Universe 28. Skeptics Guide to the Universe 1 pt. 9,361
  9. Avatar for DSN @ Home 29. DSN @ Home 1 pt. 9,313
  10. Avatar for CHNO Junkies 30. CHNO Junkies 1 pt. 9,287
  1. Avatar for aendgraend 161. aendgraend Lv 1 5 pts. 9,476
  2. Avatar for sjoerdouwe 162. sjoerdouwe Lv 1 5 pts. 9,476
  3. Avatar for phi16 163. phi16 Lv 1 5 pts. 9,475
  4. Avatar for Bearpaw 164. Bearpaw Lv 1 4 pts. 9,475
  5. Avatar for KingLear 165. KingLear Lv 1 4 pts. 9,475
  6. Avatar for damadeo 166. damadeo Lv 1 4 pts. 9,475
  7. Avatar for w513180 167. w513180 Lv 1 4 pts. 9,475
  8. Avatar for Cyanoia 168. Cyanoia Lv 1 4 pts. 9,475
  9. Avatar for boiled 169. boiled Lv 1 4 pts. 9,475
  10. Avatar for FreeFolder 170. FreeFolder Lv 1 4 pts. 9,474

Comments

mottiger Lv 1

puzzle is open on the design overview page but the status is unreleased.
are you working on it right now to bring it up?

BootsMcGraw Lv 1

I'm not sure if any of the other top scorers on this puzzle are seeing this, but I am finding that saturating this helix with aromatics is producing the highest scores.

I doubt highly that a real-life helix could contain so many tryptophans, tyrosines, and phenylalanines, yet remain a stable structure.

We've seen this scoring bug, before.