579 (<15): Beginner CASP10 Refinement Puzzle: TR662

Closed since over 13 years ago

Summary

• Created: June 15, 2012
• Expires: June 24, 2012 at 12:00 UTC
• Max points: 100

Description

This is the fourth CASP10 Refinement Target. This model was the best server prediction for target T0662, generated by the Zhang server. We've been told that ~84% of this model matches the native, so you just need to find which 16% to refine! More info in the puzzle comments. For players with fewer than 15 global points.

Top groups

• 1. L'Alliance Francophone 100 pts. 9,635
• 2. Contenders 1 pt. 9,569

Top soloists

• 1. TheVogfather 100 pts. 9,694
• 2. Ruckieboy 90 pts. 9,674
• 3. mattya1089 81 pts. 9,639
• 4. Deleted player pts. 9,635
• 5. nmeddy@hotmail.com 65 pts. 9,620
• 6. damadeo 57 pts. 9,620
• 7. AeneasIII 51 pts. 9,611
• 8. Mission Failed 45 pts. 9,600
• 9. bojler 40 pts. 9,591
• 10. al_stoybarn 35 pts. 9,590

Comments

[beta_helix]

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

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This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=110&view=refinement

Note that the organizers give us this as a hint:

"N-term res. 1-4 are disordered in the native structure and removed from the starting model. Starting GDT_TS=84."

So, the first 4 residues have been deleted.

GDT_TS=84 essentially means that 84% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...