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584: Advanced CASP10 Refinement Puzzle: TR679

Closed since almost 14 years ago

Advanced Advanced Advanced Advanced Overall Overall Overall Overall Prediction Prediction Prediction Prediction

Summary

Created
June 25, 2012
Expires
Max points
100
Description

Not only is the eighth CASP10 Refinement Target 223 residues, but this best server prediction for target T0679 was generated by the RosettaServer (using Rosetta@home). Because of this, we are giving you the Rosetta model as a template using the Alignment Tool minus the regions the CASP assesors have told us are incorrect; start by threading it and fixing the cutpoints. This one will be tough, so we are giving you 10 days. More info in the puzzle comments.

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Comments

beta_helix Staff Lv 1

the chain 25-45 runs right down the middle of the puzzle clashing with everything. Use the cut tool to move it outside.

beta_helix Staff Lv 1

The CASP organizers (who have seen the native solved structure of this protein) have told us:

"Regions showing significant deviation: 25-45, 146-156, 187-197."

These are the 3 regions that you'll need to work on, after you thread the Rosetta model using the Alignment Tool.

You'll probably want to freeze the rest of the protein while you initially refine these 3 regions.

brow42 Lv 1

the chain 25-45 runs right down the middle of the puzzle clashing with everything. Use the cut tool to move it outside.