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595: 30 Residue Symmetric Trimer Freestyle

Closed since over 13 years ago

Intermediate Intermediate Overall Overall Design Design Symmetry Symmetry

Summary

Created: June 27, 2012
Expires: July 18, 2012 at 08:00 UTC
Max points: 100

Description

This is a small (30 residue) symmetric trimer design puzzle; there will be three symmetric chains to play with. We saw some very interesting structures for the related 20 residue puzzle (Puzzle 553), but ten extra residues, and three-fold symmetry, should make this a very different challenge. Remember, a symmetric protein relies not only on how well folded each part is, but also on how well they interface together - and a symmetric trimer can be thought of as having three 2-fold interfaces. Stay tuned for higher-order symmetries, like tetrahedra and octahedra!