601 (<150): CASP10 Refinement Puzzle: TR723

Closed since over 13 years ago

Summary

• Created: July 15, 2012
• Expires: July 28, 2012 at 23:00 UTC
• Max points: 100

Description

This is the twelfth CASP10 Refinement Target. This model was the best server prediction for target T0723, generated by the Matrix server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments. For players with fewer than 150 global points.

Top groups

• 1. BOINC@Poland 100 pts. 10,739
• 2. Anthropic Dreams 71 pts. 10,666
• 3. Eὕρηκα! Heureka! 49 pts. 10,633
• 4. L'Alliance Francophone 33 pts. 10,619
• 5. TT-group 22 pts. 10,618
• 6. :) 14 pts. 10,541
• 7. Edugeek 8 pts. 10,516
• 8. DSN @ Home 5 pts. 10,502
• 9. Gargleblasters 3 pts. 10,480
• 10. 7Monkeys 2 pts. 9,332

Top soloists

• 1. greepski 100 pts. 10,999
• 2. phallicies 98 pts. 10,911
• 3. Foreman2317 95 pts. 10,834
• 4. Rispervisper 92 pts. 10,820
• 5. sheerbliss 90 pts. 10,776
• 6. andrewxc 87 pts. 10,752
• 7. wosser1 85 pts. 10,750
• 8. Ben666 82 pts. 10,741
• 9. kitek314_pl 80 pts. 10,739
• 10. farlfr 77 pts. 10,681

Comments

[beta_helix]

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

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This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=173

Note that the organizers gave us this hint:

"Starting model GDT_TS=85."

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...