601 (<150): CASP10 Refinement Puzzle: TR723

Closed since over 13 years ago

Summary

• Created: July 15, 2012
• Expires: July 28, 2012 at 23:00 UTC
• Max points: 100

Description

This is the twelfth CASP10 Refinement Target. This model was the best server prediction for target T0723, generated by the Matrix server. We've been told that ~85% of this model matches the native, so you just need to find which 15% to refine! More info in the puzzle comments. For players with fewer than 150 global points.

Top groups

• 11. Deleted group pts. 9,245
• 12. null pointer exception 1 pt. 9,245
• 13. Geekdo 1 pt. 9,114
• 14. Russian team 1 pt. 8,364
• 15. Beta Folders 1 pt. 8,364
• 16. Biology-6th 1 pt. 8,364

Top soloists

• 11. lzhchild 75 pts. 10,676
• 12. KingFrog 73 pts. 10,666
• 13. WeiKA 71 pts. 10,645
• 14. SuperBEEP 69 pts. 10,633
• 15. bullmoose3 67 pts. 10,631
• 16. multaq 65 pts. 10,619
• 17. Tycho. 63 pts. 10,618
• 18. Omexamorph 61 pts. 10,611
• 19. tela 59 pts. 10,609
• 20. Zangetsu 57 pts. 10,609

Comments

[beta_helix]

If you are new to Foldit, here are detailed instructions to get you started:
http://fold.it/portal/node/988864

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This is the page for this CASP10 refinement target:
http://predictioncenter.org/casp10/target.cgi?id=173

Note that the organizers gave us this hint:

"Starting model GDT_TS=85."

GDT_TS=85 essentially means that 85% of the model superimposes correctly onto the native structure:

en.wikipedia.org

Global distance test

The global distance test (GDT), also written as GDT_TS to represent "total score", is a measure of similarity between two protein structures with known amino acid correspondences (e.g. identical amino acid sequences) but different tertiary structures. It is most commonly used to compare the results of protein structure prediction to the experimentally determined structure as measured by X-ray crystallography, protein NMR, or, increasingly, cryoelectron microscopy. The metric was developed by Ada...