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625: Sepsis Puzzle

Closed since over 13 years ago

Intermediate Overall Design

Summary

Created
July 25, 2012
Expires
Max points
100
Description

Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by extending a specific loop region of this protein. Please build upon this region, and extend it to make additional hydrogen bond interactions with the sugar. The best Foldit designs will then be used to generate potential pathogen capture reagents. Please read the blogpost for more info and if you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle.

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Comments

Susume Lv 1

Tip: To see the parts of the sugar that you can bond to, check Show bonds (non-protein) and Show bondable atoms in the View menu. Make sure Show bonds (loop) and Show bonds (sidechain) are also on. Blue can bond to red, and purple can bond to either blue or red.

XBane Lv 1

current.GetSegmentEnergySubscore(M,"bonding") does not return the same value for the ligand as the Tab key.

Seth Cooper Staff Lv 1

Thanks for reporting the score discrepancy in scripting. The tab key is reporting the correct number. That has been fixed and will be part of the next update.

Deleted user

Is this puzzle closed, open or lost in-between? It's 2:13 past closing time but still shows "Active" and no points assigned.