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626: Slightly Different Freestyle Puzzle

Closed since over 13 years ago

Advanced Overall Prediction

Summary

Created
September 06, 2012
Expires
Max points
100
Description

We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. Unlike previous prediction puzzles, however, we are giving you a slightly different scoring function.

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Comments

beta_helix Staff Lv 1

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 7 & 68 are highly predicted to be part of a helix. However, the Valines at residues 31, 35, 43, 52, 88, 97, 101 & 120 are highly predicted to be in a sheet.

beta_helix Staff Lv 1

This is exactly what we are trying to find out by giving you a slightly different scoring function.
We will repost this as a Quick Puzzle with the regular scoring function for comparison.

Bletchley Park Lv 1

In what way is a scoring function related to the stiffness of a structure ? I would think that the stiffness is not depending on a score. Can you please explain this ?

beta_helix Staff Lv 1

It is very strange that this puzzle would be more stiff than any other freestyle extended chain that we give you (since they are generated in the exact same way).

The only difference here (other than the amino acid sequence, obviously) is the score function.

It will be interesting to see if reposting the exact same puzzle with the traditional Foldit scoring function gets rid of this stiffness.

If not, then there might be something else going on!