626: Slightly Different Freestyle Puzzle

Closed since over 13 years ago

Summary

• Created: September 06, 2012
• Expires: September 13, 2012 at 21:00 UTC
• Max points: 100

Description

We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. Unlike previous prediction puzzles, however, we are giving you a slightly different scoring function.

Top groups

• 1. Contenders 100 pts. 10,810
• 2. Void Crushers 87 pts. 10,736
• 3. Anthropic Dreams 76 pts. 10,714
• 4. Beta Folders 65 pts. 10,687
• 5. L'Alliance Francophone 56 pts. 10,682
• 6. foldeRNA 48 pts. 10,640
• 7. Go Science 41 pts. 10,629
• 8. Richard Dawkins Foundation 34 pts. 10,616
• 9. FoldIt@Netherlands 29 pts. 10,606
• 10. Gargleblasters 24 pts. 10,606

Top soloists

• 1. Timo van der Laan 100 pts. 10,736
• 2. Susume 99 pts. 10,714
• 3. steveB 98 pts. 10,700
• 4. stg123123 97 pts. 10,687
• 5. Ch Garnier 96 pts. 10,680
• 6. Bletchley Park 95 pts. 10,679
• 7. smilingone 93 pts. 10,676
• 8. mimi 92 pts. 10,673
• 9. jakbinimbol 91 pts. 10,665
• 10. rsosborne 90 pts. 10,640

Comments

[beta_helix]

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 7 & 68 are highly predicted to be part of a helix. However, the Valines at residues 31, 35, 43, 52, 88, 97, 101 & 120 are highly predicted to be in a sheet.

[spmm]

this is really stiff to move even on CI= 0.3

[beta_helix]

This is exactly what we are trying to find out by giving you a slightly different scoring function.
We will repost this as a Quick Puzzle with the regular scoring function for comparison.

[Bletchley Park]

In what way is a scoring function related to the stiffness of a structure ? I would think that the stiffness is not depending on a score. Can you please explain this ?

[beta_helix]

It is very strange that this puzzle would be more stiff than any other freestyle extended chain that we give you (since they are generated in the exact same way).

The only difference here (other than the amino acid sequence, obviously) is the score function.

It will be interesting to see if reposting the exact same puzzle with the traditional Foldit scoring function gets rid of this stiffness.

If not, then there might be something else going on!