Placeholder image of a protein
Icon representing a puzzle

626: Slightly Different Freestyle Puzzle

Closed since over 13 years ago

Advanced Overall Prediction

Summary

Created
September 06, 2012
Expires
Max points
100
Description

We are giving you this currently unsolved protein as an extended chain. Use all your skills to fold it up as best as you can. Unlike previous prediction puzzles, however, we are giving you a slightly different scoring function.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 10,810
  2. Avatar for Void Crushers 2. Void Crushers 87 pts. 10,736
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 76 pts. 10,714
  4. Avatar for Beta Folders 4. Beta Folders 65 pts. 10,687
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 56 pts. 10,682
  6. Avatar for foldeRNA 6. foldeRNA 48 pts. 10,640
  7. Avatar for Go Science 7. Go Science 41 pts. 10,629
  8. Avatar for Richard Dawkins Foundation 8. Richard Dawkins Foundation 34 pts. 10,616
  9. Avatar for FoldIt@Netherlands 9. FoldIt@Netherlands 29 pts. 10,606
  10. Avatar for Gargleblasters 10. Gargleblasters 24 pts. 10,606
  1. Avatar for marie_s 41. marie_s Lv 1 61 pts. 10,434
  2. Avatar for christioanchauvin 42. christioanchauvin Lv 1 60 pts. 10,428
  3. Avatar for johnmitch 43. johnmitch Lv 1 59 pts. 10,425
  4. Avatar for Bautho 44. Bautho Lv 1 58 pts. 10,423
  5. Avatar for meatexplosion 45. meatexplosion Lv 1 58 pts. 10,409
  6. Avatar for truestone 46. truestone Lv 1 57 pts. 10,402
  7. Avatar for Cerzax 47. Cerzax Lv 1 56 pts. 10,402
  8. Avatar for hansvandenhof 48. hansvandenhof Lv 1 55 pts. 10,396
  9. Avatar for Mr_Jolty 49. Mr_Jolty Lv 1 55 pts. 10,393
  10. Avatar for Deleted player 50. Deleted player pts. 10,387

Comments

beta_helix Staff Lv 1

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 7 & 68 are highly predicted to be part of a helix. However, the Valines at residues 31, 35, 43, 52, 88, 97, 101 & 120 are highly predicted to be in a sheet.

beta_helix Staff Lv 1

This is exactly what we are trying to find out by giving you a slightly different scoring function.
We will repost this as a Quick Puzzle with the regular scoring function for comparison.

Bletchley Park Lv 1

In what way is a scoring function related to the stiffness of a structure ? I would think that the stiffness is not depending on a score. Can you please explain this ?

beta_helix Staff Lv 1

It is very strange that this puzzle would be more stiff than any other freestyle extended chain that we give you (since they are generated in the exact same way).

The only difference here (other than the amino acid sequence, obviously) is the score function.

It will be interesting to see if reposting the exact same puzzle with the traditional Foldit scoring function gets rid of this stiffness.

If not, then there might be something else going on!