627: 30 Residue Symmetric Dimer of Dimers Freestyle
Closed since over 13 years ago
Intermediate Overall Design SymmetrySummary
- Created
- September 06, 2012
- Expires
- Max points
- 100
This is a small (30 residue) symmetric tetramer design puzzle; there will be four symmetric chains to manage. Symmetry becomes more complicated past three chains; for example, tetramers can be arranged in a ring (called "C4" symmetry) or as a dimer of dimers ("D2" or "two-by-two" symmetry). The dimer of dimers is much more common in nature, so we'll be exploring that type of symmetry first. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. This dimer of dimers has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD. Stay tuned for higher-order symmetries; it only gets crazier from here!
