627: 30 Residue Symmetric Dimer of Dimers Freestyle
Closed since over 13 years ago
Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry SymmetrySummary
- Created
- September 06, 2012
- Expires
- Max points
- 100
This is a small (30 residue) symmetric tetramer design puzzle; there will be four symmetric chains to manage. Symmetry becomes more complicated past three chains; for example, tetramers can be arranged in a ring (called "C4" symmetry) or as a dimer of dimers ("D2" or "two-by-two" symmetry). The dimer of dimers is much more common in nature, so we'll be exploring that type of symmetry first. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. This dimer of dimers has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD. Stay tuned for higher-order symmetries; it only gets crazier from here!
