633: Return of the Tissue Regeneration Design Puzzle

Closed since over 13 years ago

Summary

• Created: September 21, 2012
• Expires: October 01, 2012 at 05:00 UTC
• Max points: 100

Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments. Note: you will need the latest update to play this puzzle.

Top groups

• 1. Contenders 100 pts. 9,358
• 2. Anthropic Dreams 88 pts. 9,342
• 3. foldeRNA 76 pts. 9,334
• 4. Go Science 66 pts. 9,330
• 5. L'Alliance Francophone 57 pts. 9,328
• 6. Beta Folders 49 pts. 9,322
• 7. Void Crushers 42 pts. 9,317
• 8. Richard Dawkins Foundation 36 pts. 9,316
• 9. Deleted group pts. 9,307
• 10. Gargleblasters 25 pts. 9,299

Top soloists

• 1. doug.ehlert 100 pts. 9,358
• 2. Bletchley Park 99 pts. 9,352
• 3. infjamc 97 pts. 9,349
• 4. jamiexq 96 pts. 9,342
• 5. johnmitch 94 pts. 9,338
• 6. hansvandenhof 93 pts. 9,334
• 7. Deleted player pts. 9,333
• 8. Rav3n_pl 90 pts. 9,332
• 9. mbinfield 88 pts. 9,329
• 10. christioanchauvin 87 pts. 9,328

Comments

[beta_helix]

This is a repost of Puzzle 571: Tissue Regeneration Design Puzzle, but with a new filter that should help with the scoring artifacts that were prevalent in that puzzle.

More background on this puzzle can be found in the original blogpost: http://fold.it/portal/node/992888

[gitwut]

I'm seeing a message in the bonus/condition box message Residue IE Score: lost (-239)

I'm guessing that it might have something to do with the Helix integrity, but pulling the helix out and rebuilding it actually lowered the value to (-275). What exactly does this mean (also, what is "IE")? I have no idea how to fix it, though I'll continue to play with it.

I asked in global but no one else knew for sure.

I've clicked on the Show button (inside the box and beneath the message) and it obscures part of the protein as if it was sunk in an opaque red liquid.

[tamirh]

I posted on the forum some info explaining what ResidueIE is.

http://fold.it/portal/node/993602

[CharlieFortsConscience]

Evening

I'll also post this on the thread that you mentioned above.

As it stands, ResidueIE info makes 633 unplayable, at least for me, once you find a negative seg score. It's like trying to play a puzzle with the 'isosurface' option on. It's swamping system/CPU resources, rendering any other work you try to do, outside of FoldClub, very difficult.

I had to shut the foldit client down, just to be able to post this feedback. It's not a 'crashing' bug, it's just a 'rapaciously thirsty' code.

[Deleted user]

This puzzle is unplayable.

http://fold.it/portal/node/993596#comment-19922

[gitwut]

I'm done with this puzzle too. It crashes after I go to sleep and crashes before I get home from work. When it doesn't crash it slows everything down to a crawl.

[beta_helix]

Is anyone that is having problems NOT using a PC?

We are trying to get this resolved ASAP, if you can help answer tamirh's questions hopefully we can find the issue quickly: http://fold.it/portal/node/993596#comment-19940

Thanks again for your patience and we really apologize for this.
When we posted it in devprev there we no reports that it was unplayable or crashed this often!

Hopefully we can get this filter working properly as it should, so we can post the many exciting design puzzles that we have lined up!