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636: 40 Residue Symmetric Dimer of Dimers Freestyle

Closed since over 13 years ago

Intermediate Overall Design Symmetry

Summary

Created
September 27, 2012
Expires
Max points
100
Description

We're moving up from the 30 residue dimer of dimers puzzle that we posted before, since increasing the length makes the produced designs more likely to fold up in nature. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. This dimer of dimers has two fundamentally different interfaces: the interface between chains A and B, and the interface between dimer AB and its partner, CD. We're really excited with some of the designs we've seen so far, and we're eager for more!

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