640: Frizzled Design Puzzle

Closed since over 13 years ago

Summary

• Created: October 11, 2012
• Expires: October 19, 2012 at 23:59 UTC
• Max points: 100

Description

You've seen this design puzzle before, but look more closely! The Frizzled protein occurs in a number of forms. Last time we gave you a form of Frizzled with a narrow pocket. This time we are giving you a form of Frizzled with a wider pocket. There are a couple of rules: You can mutate any residue on the helix but none on Frizzled and the small binding helix must stay in helical shape. We've also added a new filter that we call "Residue Interaction Energy". Natural proteins avoid putting Tryptophan, Phenylalanine, and Tyrosine on the surface. However, Foldit often gives a score bonus if you load up the surface of your design with Tryptophan. The Residue Interaction Energy filter helps to counteract that, helping you make better designs. Enjoy and thanks for all of your efforts!

Top groups

• 1. Contenders 100 pts. 10,118
• 2. Go Science 85 pts. 10,117
• 3. Anthropic Dreams 72 pts. 10,117
• 4. foldeRNA 61 pts. 10,117
• 5. Beta Folders 51 pts. 10,117
• 6. Void Crushers 42 pts. 10,117
• 7. Russian team 35 pts. 10,114
• 8. L'Alliance Francophone 28 pts. 10,111
• 9. Gargleblasters 23 pts. 10,094
• 10. CHNO Junkies 19 pts. 10,093

Top soloists

• 141. Bruno Kestemont 6 pts. 10,064
• 142. Lougrims 6 pts. 10,062
• 143. Petrifolder 6 pts. 10,062
• 144. dflear 6 pts. 10,061
• 145. ncm25_OLD 5 pts. 10,061
• 146. justjustin 5 pts. 10,061
• 147. alwen 5 pts. 10,060
• 148. Origami314 5 pts. 10,059
• 149. andrewxc 5 pts. 10,059
• 150. DrMistry 5 pts. 10,058

Comments

[beta_helix]

for more information about this puzzle:
http://fold.it/portal/node/993721