657: Blind Electron Density 3

Closed since over 13 years ago

Summary

• Created: November 27, 2012
• Expires: December 04, 2012 at 23:00 UTC
• Max points: 100

Description

This is our third electron density puzzle with real data. Like our second puzzle, we were able to pinpoint which regions belong to a single copy. Try to fit the protein into the density to get the best score!

Top groups

• 1. Void Crushers 100 pts. 8,174
• 2. Anthropic Dreams 86 pts. 8,168
• 3. Go Science 73 pts. 7,766
• 4. SETI.Germany 62 pts. 6,978
• 5. Contenders 52 pts. 6,035
• 6. foldeRNA 43 pts. 5,426
• 7. L'Alliance Francophone 36 pts. 5,224
• 8. Gargleblasters 30 pts. 5,192
• 9. Deleted group pts. 4,076
• 10. Beta Folders 20 pts. 4,054

Top soloists

• 1. steveB 100 pts. 8,154
• 2. Susume 99 pts. 8,143
• 3. karstenw 98 pts. 8,117
• 4. Timo van der Laan 96 pts. 8,049
• 5. utaca 95 pts. 7,952
• 6. gmn 94 pts. 7,837
• 7. pauldunn 92 pts. 7,766
• 8. Bautho 91 pts. 6,825
• 9. doug.ehlert 90 pts. 6,035
• 10. Madde 88 pts. 5,460

Comments

[jflat06]

You can find secondary structure predictions from Jpred here:

http://fold.it/portal/node/993971

[steveB]

There appears to be less detail in the ED mesh on this puzzle, or you have changed the programme slightly. The threshold slider on this puzzle is best set to maximum, ie as far to the left as possible

[jflat06]

The density quality will vary from protein to protein, as the resolution of the data gathered from the experimental methods isn't always the same.

[steveB]

I understand from Brow42 that the first posting of this puzzle didn't work because the ED data exceeded 128 Mb. Was there any data loss in re-issuing the puzzle with a smaller data file ?

[jflat06]

The original puzzle was posted as an untrimmed case, where the entire density cell was included (including the extraneous bits of density from other copies).

We decided to repost the puzzle as the trimmed case, as the density is smaller. I believe what was lost was only the extra bits of density, and not any of the resolution.

The trimmed case isn't 100% blind, as we decided what to trim based on the actual solved structure - however, in these last 2 cases, the trimming could very feasibly be done without knowledge of the structure, so it's still a very cool result.