Placeholder image of a protein
Icon representing a puzzle

659: Re-Return of the Tissue Regeneration Design Puzzle

Closed since about 13 years ago

Intermediate Overall Design

Summary

Created
December 05, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments.

Top groups

  1. Avatar for Origami 2 21. Origami 2 1 pt. 9,232
  2. Avatar for Freedom Folders 22. Freedom Folders 1 pt. 9,230
  3. Avatar for Deleted group 23. Deleted group pts. 9,229
  4. Avatar for Eὕρηκα! Heureka! 24. Eὕρηκα! Heureka! 1 pt. 9,216
  5. Avatar for Czech National Team 25. Czech National Team 1 pt. 9,206
  6. Avatar for Team Germany 26. Team Germany 1 pt. 9,197
  7. Avatar for Nerdfighters 27. Nerdfighters 1 pt. 9,177
  8. Avatar for DSN @ Home 28. DSN @ Home 1 pt. 9,177
  9. Avatar for WOOT 29. WOOT 1 pt. 9,162
  10. Avatar for BOINC@Poland 30. BOINC@Poland 1 pt. 9,160
  1. Avatar for stg123123
    1. stg123123 Lv 1
    100 pts. 9,361
  2. Avatar for gmn 2. gmn Lv 1 99 pts. 9,359
  3. Avatar for MooMooMan 3. MooMooMan Lv 1 98 pts. 9,359
  4. Avatar for Azukay 4. Azukay Lv 1 96 pts. 9,359
  5. Avatar for karstenw 5. karstenw Lv 1 95 pts. 9,358
  6. Avatar for harp 6. harp Lv 1 93 pts. 9,358
  7. Avatar for Bletchley Park 7. Bletchley Park Lv 1 92 pts. 9,358
  8. Avatar for pvc78 8. pvc78 Lv 1 91 pts. 9,358
  9. Avatar for mimi 9. mimi Lv 1 89 pts. 9,358
  10. Avatar for auntdeen 10. auntdeen Lv 1 88 pts. 9,357

Comments

tamirh Lv 1

This is a repost of Puzzle 571: Tissue Regeneration Design Puzzle, but with a new filter that should help with the scoring artifacts that were prevalent in that puzzle. We tried this with puzzle 633 but the ResidueIE filter was broken and this caused windows machines to crash. With the ResidueIE filter fixed, we wanted to try the puzzle again.

More background on this puzzle can be found in the original blogpost: http://fold.it/portal/node/992888