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659: Re-Return of the Tissue Regeneration Design Puzzle

Closed since about 13 years ago

Intermediate Overall Design

Summary

Created
December 05, 2012
Expires
Max points
100
Description

We are giving you a 10 residue helix positioned over a hydrophobic groove where binding occurs in nature. This native binding region in marked by unfrozen side chains. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. If you are new to Foldit, make sure you have completed Intro Puzzle 5-2, and 7-1 through 7-4 before trying this puzzle. More details in the puzzle comments.

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Comments

tamirh Lv 1

This is a repost of Puzzle 571: Tissue Regeneration Design Puzzle, but with a new filter that should help with the scoring artifacts that were prevalent in that puzzle. We tried this with puzzle 633 but the ResidueIE filter was broken and this caused windows machines to crash. With the ResidueIE filter fixed, we wanted to try the puzzle again.

More background on this puzzle can be found in the original blogpost: http://fold.it/portal/node/992888