Placeholder image of a protein
Icon representing a puzzle

680: Solo Hand-Folding Sepsis Puzzle

Closed since about 13 years ago

Intermediate Overall Design Hand-Folding

Summary

Created
February 26, 2013
Expires
Max points
100
Description

Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by allowing you to redesign & insert up to 10 residues to form additional hydrogen bonds with the sugar. To encourage this, only GUI scripts are allowed, and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You will be able to load in your solutions from the first puzzle and refine them with scripting and sharing. Please read the new blogpost & puzzle comments for more details.

Top groups

  1. Avatar for Crunching Family 31. Crunching Family 1 pt. 8,291
  2. Avatar for Taiwan Tainan First Senior High 32. Taiwan Tainan First Senior High 1 pt. 8,267
  3. Avatar for null pointer exception 33. null pointer exception 1 pt. 8,258
  4. Avatar for Davidson College Wildcats 34. Davidson College Wildcats 1 pt. 7,654
  5. Avatar for Window Group 35. Window Group 1 pt. 7,647
  6. Avatar for Deleted group 36. Deleted group pts. 7,647
  1. Avatar for retiredmichael 211. retiredmichael Lv 1 2 pts. 8,488
  2. Avatar for kludbrook 212. kludbrook Lv 1 2 pts. 8,488
  3. Avatar for kdieber 213. kdieber Lv 1 2 pts. 8,488
  4. Avatar for Nicholasalan 214. Nicholasalan Lv 1 2 pts. 8,487
  5. Avatar for littlelisper 215. littlelisper Lv 1 2 pts. 8,486
  6. Avatar for haabermaaster 216. haabermaaster Lv 1 2 pts. 8,486
  7. Avatar for meneater3333 217. meneater3333 Lv 1 2 pts. 8,485
  8. Avatar for The_Deputy 218. The_Deputy Lv 1 2 pts. 8,485
  9. Avatar for informator 219. informator Lv 1 2 pts. 8,485
  10. Avatar for Helix Newton 220. Helix Newton Lv 1 2 pts. 8,485

Comments

tamirh Lv 1

I pulled out the ligand to find out if the ligand would cause the IE to change. It does, but only negatively. With the ligand completely removed, the IE is basically the same as when it is there.

I then replaced the ligand with some ALA to test out if it was a difference between ligands and normal aa. The buried TYR still scored poorly. So it looks like it's just a function of the interaction energy and positioning itself, not an issue with it being a ligand.