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690: 76 Residue Dimer

Closed since about 13 years ago

Advanced Overall Design Symmetry

Summary

Created
March 21, 2013
Expires
Max points
100
Description

This is a 76 residue symmetric dimer design puzzle. You will be able to load in your monomer solutions from "687: 76 Residue Monomer Repost".

A symmetric protein relies not only on how well folded each part is, but also on how well they interface together; see the latest blogpost about this: http://fold.it/portal/node/993871 There are 4 filters enabled in this puzzle. They are slow to compute, so you may want to check "Disable slow filters" in the behavior tab for when you are manually pulling and running your scripts. The ResidueIE filter ensures PHY, TYR, and TRP residues are scoring well. The "Core Exists" filter ensures the number of residues in the core is between 30% and 70%. The "Polar Core" filter that the residues in the core are properly hydrophobic. The "Layer Design" filter looks at the interactions of the residues based on the surface area of the protein. Residues can be either in the core, on the boundary or on the surface of the protein. Depending on the surroundings, the "Layer Design" filter will give you a bonus if your amino acid matches what it was expecting. Press TAB on each residue to find out more about these filters.

Top groups

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  6. Avatar for test_group1 26. test_group1 1 pt. 0
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  7. Avatar for mirjamvandelft 177. mirjamvandelft Lv 1 2 pts. 8,343
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  10. Avatar for Dixie2 180. Dixie2 Lv 1 2 pts. 8,282

Comments

beta_helix Staff Lv 1

Due to the new filters slowing things down, and since there are many design puzzles up, we've extended this deadline by 1 week.