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697: Second Hand-Folding Sepsis Puzzle

Closed since almost 13 years ago

Intermediate Overall Design Hand-Folding

Summary

Created
April 05, 2013
Expires
Max points
100
Description

Sugar molecules such as the one here are coated on the surface of many human pathogens. We are attempting to increase the protein-sugar binding interactions by allowing you to redesign & insert up to 6 residues to form additional hydrogen bonds with the sugar. To encourage this, only GUI scripts are allowed, and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You will be able to load in your solutions from the first puzzle and refine them with scripting and sharing. Please read the new puzzle comments for more details. AND PLEASE NOTICE that Valine 32 can be mutated!

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Comments

beta_helix Staff Lv 1

Please read the new Blog Entry about this puzzle: http://fold.it/portal/node/994592

PLEASE NOTE that Valine 32 can be mutated!
_______________

If you are new to Foldit, make sure you have completed Intro Puzzles 7-1 through 7-4 before trying this puzzle.
_______________

This puzzle has the ResidueIE filter on (to try to ensure that PHE, TYR, and TRP residues are scoring properly) and we've increased the Ligand Score by a factor of 10 to promote interactions with the sugar.

Tip: To see the parts of the sugar that you can bond to, check Show bonds (non-protein) and Show bondable atoms in the View menu. Make sure Show bonds (loop) and Show bonds (sidechain) are also on. Blue can bond to red, and purple can bond to either blue or red.