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725: Quick 60 Residue Tetramer Redesign

Closed since almost 13 years ago

Intermediate Overall Design Symmetry

Summary

Created
June 04, 2013
Expires
Max points
100
Description

This is a 60 residue symmetric tetramer design puzzle. The starting structure is a solution to Puzzle 691 that was shared with us by MurloW. The scientists at the Baker Lab like the topology of this solution, but simulations predict that this amino acid sequence will not fold up properly from an extended chain. Help us redesign this solution into a folding protein! The ResidueIE and "Core Exists" filters will make sure PHY, TYR, and TRP residues are scoring well, and that the protein core includes at least 35% of the residues. We look forward to seeing your mutations to this fold, although you are free to redesign the entire protein in this puzzle.

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Comments

BootsMcGraw Lv 1

Wiggle doesn't work, even with the "Disable Slow Filters" box checked and the CI pulled way down. Neither does Shake. Mutate barely works.

If anyone else is experiencing this, I'll file a trouble ticket.

drumpeter18yrs9yrs Lv 1

there are some problems with wiggle. shake seems to be slow. however, wiggling sidechains seems to work the best. If there are a lot of bands, wiggle backbone does work a little bit; but still, not very well. if you select sheets and helices one by one, mutate works fairly fast.