735: Player-Solution Loop Redesign: Round 2
Closed since over 12 years ago
Intermediate Overall DesignSummary
- Created
- June 25, 2013
- Expires
- Max points
- 100
This is a puzzle where you can redesign part of a player-designed protein. Galaxie's top-scoring solution from Puzzle 720 shows promise in the Baker Lab's folding simulations, but one loop seems to be a little troublesome. In Puzzle 734, you were allowed to design just this short loop, but now you can redesign an entire helix. Like the last puzzle, you can insert up to four residues and mutate residues near the helix, but the rest of the protein is frozen. The scientists at the Baker Lab like the general placement of this helix, so there is also an RMSD condition for the helix residues. You can load in solutions from Puzzle 734.
