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738: De-novo Freestyle 26: Hand-folding Round

Closed since almost 13 years ago

Intermediate Overall Prediction Hand-Folding

Summary


Created
July 02, 2013
Expires
Max points
100
Description

This is a funny little protein that was designed by scientists in the Baker lab. It has only been crystallized as a dimer, but it is known to exist in solution as a monomer. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing. The secondary structure predictions are provided on the starting model, with more details posted in the puzzle comments.

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Comments


bkoep Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 6 & 7 are highly predicted to be part of a sheet. However, the Valines at residues 64 & 65 are highly predicted to be in a helix!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).


If you are a new Foldit player, please make sure you have completed all these tutorials before trying this puzzle:

  • lonely sheets,
  • lock and lower,
  • rebuild,
  • structure and rebuild,
  • control over clashing.