756: Unsolved Salmonella Bacteriophage: Cryo-electron microscopy

Closed since over 12 years ago

Summary

• Created: August 04, 2013
• Expires: August 15, 2013 at 03:00 UTC
• Max points: 100

Description

The Unsolved Salmonella Bacteriophage protein that you have been working on (in puzzles 737, 740, 749) has Cryo-electron microscopy (cryo-EM) data that we can use. We are giving you the same puzzle, but this time with Cryo-EM data as an Electron Density puzzle! This is the best available experimental data that exists for this protein, so we hope it is useful to you. You can load in your previous solutions from the previous puzzles (737, 740, 749) and can find more details in the puzzle comments.

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Comments

[beta_helix]

NOTE: If you did not manually save a solution that you want to use from puzzles (737, 740, or 749), you can go back to those puzzles, manually save it, and the solution should appear in your manual saves for this puzzle.

Original secondary structure predictions from the SAM server are here:
http://fold.it/portal/node/995398#comment-23593

More info about Cryo-electron microscopy here:

en.wikipedia.org

Cryogenic electron microscopy

Cryogenic electron microscopy (cryo-EM) is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures. For biological specimens, the structure is preserved by embedding in an environment of vitreous ice. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane. While development of the technique began in the 1970s, recent advances in detector technology and software algorithms have allowed for the dete In...