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783: 60 Residue Symmetric Dimer with a Disulfide

Closed since over 12 years ago

Intermediate Intermediate Overall Overall Design Design Symmetry Symmetry

Summary

Created: September 24, 2013
Expires: October 01, 2013 at 19:00 UTC
Max points: 100

Description

This is a 60 residue symmetric dimer design puzzle; there will be two symmetric chains to manage. This puzzle also contains a disulfide filter: you will receive a bonus for making one disulfide bond between the two subunits, but there is no bonus for a disulfide bond between two residues of the same subunit. Remember, a symmetric protein relies not only on how well-folded each chain is, but also on how well they interface together. See the blog post about this for more information. In addition to the disulfide filter, there are two other filters enabled on this puzzle: the Residue IE Score monitors that all PHY, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions.