Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 12 years ago

Beginner Beginner

Summary

Created
July 29, 2013
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for Gargleblasters
    1. Gargleblasters
    100 pts. 10,719
  2. Avatar for Beta Folders 2. Beta Folders 91 pts. 10,714
  3. Avatar for Go Science 3. Go Science 83 pts. 10,714
  4. Avatar for xkcd 4. xkcd 75 pts. 10,706
  5. Avatar for SETIKAH@KOREA 5. SETIKAH@KOREA 68 pts. 10,691
  6. Avatar for Void Crushers 6. Void Crushers 61 pts. 10,686
  7. Avatar for SVC Bioinformatics 7. SVC Bioinformatics 55 pts. 10,681
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 49 pts. 10,659
  9. Avatar for Piratenpartei Deutschland 9. Piratenpartei Deutschland 44 pts. 10,652
  10. Avatar for Tennessee Tech Biochemistry 10. Tennessee Tech Biochemistry 39 pts. 10,649
  1. Avatar for Aaron72 341. Aaron72 Lv 1 20 pts. 10,560
  2. Avatar for Diced 342. Diced Lv 1 20 pts. 10,560
  3. Avatar for chas_roberts 343. chas_roberts Lv 1 20 pts. 10,559
  4. Avatar for huhlim 344. huhlim Lv 1 20 pts. 10,559
  5. Avatar for JackONeill12 345. JackONeill12 Lv 1 20 pts. 10,559
  6. Avatar for nafnaf93 346. nafnaf93 Lv 1 20 pts. 10,559
  7. Avatar for balewis 347. balewis Lv 1 20 pts. 10,559
  8. Avatar for PederNL 348. PederNL Lv 1 19 pts. 10,559
  9. Avatar for abio111 349. abio111 Lv 1 19 pts. 10,559
  10. Avatar for welale2013 350. welale2013 Lv 1 19 pts. 10,558

Comments