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805: Ferredoxin Pentamer Design

Closed since over 12 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Symmetry Symmetry Symmetry Symmetry Symmetry Symmetry

Summary

Created: November 05, 2013
Expires: November 13, 2013 at 01:00 UTC
Max points: 100

Description

In this puzzle you can redesign a protein that was originally designed in the Baker Lab. This ferredoxin-like fold is very stable as a monomer, and the Baker Lab is trying to redesign it to form a symmetric pentamer. The backbone is locked for most of the protein, but you can mutate surface residues to improve the pentamer interface. You can also design a 10 residue extension at the N- or C-terminus to improve the binding interface between monomer units; reset the puzzle to alternate between the extended N- and C-terminus versions. This puzzle also includes a Residue IE filter, which monitors that all PHE, TYR, and TRP residues are scoring well.