Placeholder image of a protein
Icon representing a puzzle

807: De-novo Cryo-electron Density: Hand-folding Round

Closed since over 12 years ago

Advanced Overall Prediction Electron Density Hand-Folding

Summary

Created
November 07, 2013
Expires
Max points
100
Description

Try to fit this extended chain into the cryo-EM density cloud to gain points. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing.

Top groups

  1. Avatar for Natural Abilities 11. Natural Abilities 7 pts. 5,815
  2. Avatar for Repro-men 12. Repro-men 5 pts. 5,774
  3. Avatar for HMT heritage 13. HMT heritage 4 pts. 5,385
  4. Avatar for Deleted group 14. Deleted group pts. 5,122
  5. Avatar for FoldIt@Netherlands 15. FoldIt@Netherlands 2 pts. 5,089
  6. Avatar for Russian team 16. Russian team 1 pt. 5,035
  7. Avatar for Curtin Crowd 17. Curtin Crowd 1 pt. 4,875
  8. Avatar for Deleted group 18. Deleted group pts. 4,710
  9. Avatar for Tennessee Tech Biochemistry 19. Tennessee Tech Biochemistry 1 pt. 3,632
  10. Avatar for Eὕρηκα! Heureka! 20. Eὕρηκα! Heureka! 1 pt. 3,010
  1. Avatar for Joryell 111. Joryell Lv 1 9 pts. 4,395
  2. Avatar for Zepp 112. Zepp Lv 1 9 pts. 4,364
  3. Avatar for eboppterp 113. eboppterp Lv 1 9 pts. 4,363
  4. Avatar for perrya 114. perrya Lv 1 8 pts. 4,350
  5. Avatar for Cerzax 115. Cerzax Lv 1 8 pts. 4,317
  6. Avatar for Laranja 116. Laranja Lv 1 8 pts. 4,301
  7. Avatar for Mike Cassidy 117. Mike Cassidy Lv 1 8 pts. 4,294
  8. Avatar for JPC119 118. JPC119 Lv 1 8 pts. 4,289
  9. Avatar for cherry39 119. cherry39 Lv 1 7 pts. 4,231
  10. Avatar for dbuske 120. dbuske Lv 1 7 pts. 4,225

Comments

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 41-42 are highly predicted to be part of a helix. However, the Valines at residue 67 and 94 are predicted to be in sheets!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).
_________________

More info about Cryo-electron microscopy here: