Placeholder image of a protein
Icon representing a puzzle

807: De-novo Cryo-electron Density: Hand-folding Round

Closed since over 12 years ago

Advanced Overall Prediction Electron Density Hand-Folding

Summary

Created
November 07, 2013
Expires
Max points
100
Description

Try to fit this extended chain into the cryo-EM density cloud to gain points. This round only GUI scripts are allowed and sharing has been disabled. After this puzzle expires, the puzzle will be re-posted and LUA scripts and sharing will be allowed. You'll be able to load in your solutions from this puzzle and use scripting and sharing.

Top groups

  1. Avatar for Natural Abilities 11. Natural Abilities 7 pts. 5,815
  2. Avatar for Repro-men 12. Repro-men 5 pts. 5,774
  3. Avatar for HMT heritage 13. HMT heritage 4 pts. 5,385
  4. Avatar for Deleted group 14. Deleted group pts. 5,122
  5. Avatar for FoldIt@Netherlands 15. FoldIt@Netherlands 2 pts. 5,089
  6. Avatar for Russian team 16. Russian team 1 pt. 5,035
  7. Avatar for Curtin Crowd 17. Curtin Crowd 1 pt. 4,875
  8. Avatar for Deleted group 18. Deleted group pts. 4,710
  9. Avatar for Tennessee Tech Biochemistry 19. Tennessee Tech Biochemistry 1 pt. 3,632
  10. Avatar for Eὕρηκα! Heureka! 20. Eὕρηκα! Heureka! 1 pt. 3,010
  1. Avatar for NicoleHewitt 151. NicoleHewitt Lv 1 3 pts. 3,291
  2. Avatar for Antibrad 152. Antibrad Lv 1 3 pts. 3,262
  3. Avatar for Andrews 153. Andrews Lv 1 3 pts. 3,224
  4. Avatar for Tyggy Too 154. Tyggy Too Lv 1 3 pts. 3,134
  5. Avatar for Hiro Protagonist 155. Hiro Protagonist Lv 1 3 pts. 3,121
  6. Avatar for johnmitch 156. johnmitch Lv 1 2 pts. 3,119
  7. Avatar for JasperD 157. JasperD Lv 1 2 pts. 3,076
  8. Avatar for galactobourico 158. galactobourico Lv 1 2 pts. 3,074
  9. Avatar for polly66017 159. polly66017 Lv 1 2 pts. 3,034
  10. Avatar for pruneau_44 160. pruneau_44 Lv 1 2 pts. 3,020

Comments

beta_helix Staff Lv 1

Here is the sequence logo predicted by the SAM server:

H = helix
E = sheet
C = loop (or coil)

The taller the letter at each position, the higher the probability of that specific secondary structure for that amino acid.

For example, the Valines at residues 41-42 are highly predicted to be part of a helix. However, the Valines at residue 67 and 94 are predicted to be in sheets!

The above predictions are already on the starting model (based on the horizontal lines in the above figure).
_________________

More info about Cryo-electron microscopy here: