811: Abeta Binder Redesign: Round 2

Closed since over 12 years ago

Summary

• Created: November 19, 2013
• Expires: November 26, 2013 at 23:00 UTC
• Max points: 100

Description

This is a follow-up puzzle to Puzzle 801b. We chose nine of the most promising solutions from that puzzle and added an extra beta-strand to each subunit of the Abeta binder—reset this puzzle to cycle through these nine starting structures. Like in Puzzle 801b, the Abeta protein backbone is frozen, and now you can mutate all residues in the binder subunits. Each chain has a separate RMSD condition, so only slight backbone movements will be tolerated, although you will be able to move the extra beta strand freely. This puzzle also includes a Residue IE filter, which monitors that all PHY, TYR, and TRP residues are scoring well. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions. See the new blog entry about this puzzle for more information and a picture of the sort of backbone configuration that we're aiming for.

Top groups

• 1. Anthropic Dreams 100 pts. 11,000
• 2. L'Alliance Francophone 85 pts. 10,977
• 3. Gargleblasters 72 pts. 10,935
• 4. Contenders 61 pts. 10,914
• 5. Deleted group pts. 10,904
• 6. Go Science 42 pts. 10,875
• 7. Beta Folders 35 pts. 10,837
• 8. Void Crushers 28 pts. 10,827
• 9. HMT heritage 23 pts. 10,789
• 10. Russian team 19 pts. 10,776

Top evolvers

• 31. mirp 1 pt. 10,825
• 32. dbuske 1 pt. 10,823
• 33. O Seki To 1 pt. 10,789
• 34. Grom 1 pt. 10,776
• 35. drumpeter18yrs9yrs 1 pt. 10,770
• 36. Rita_Gat 1 pt. 10,757
• 37. vakobo 1 pt. 10,753
• 38. Hunybadger 1 pt. 10,723
• 39. diamond_dust 1 pt. 10,722
• 40. vilge 1 pt. 10,715