831: Abeta Loop Closure B

Closed since about 12 years ago

Summary

• Created: January 07, 2014
• Expires: January 26, 2014 at 23:00 UTC
• Max points: 100

Description

This puzzle builds on a piecewise design solution from Puzzle 808. Build loops to close the cutpoints between secondary structure elements to create an Abeta-binding protein! The two starting structures were derived from a single solution by gitwut and martinzblavy, but have different loop arrangements. Reset the puzzle to cycle through both starting structures. See the puzzle comments for more details. This puzzle will be open for two weeks.

Top groups

• 1. Contenders 100 pts. 12,383
• 2. L'Alliance Francophone 83 pts. 12,346
• 3. Anthropic Dreams 68 pts. 12,212
• 4. Beta Folders 55 pts. 12,127
• 5. Void Crushers 44 pts. 12,079
• 6. Go Science 35 pts. 11,954
• 7. Gargleblasters 27 pts. 11,924
• 8. Deleted group pts. 11,845
• 9. HMT heritage 16 pts. 11,836
• 10. Russian team 12 pts. 11,745

Top soloists

• 21. O Seki To 64 pts. 11,834
• 22. hpaege 62 pts. 11,822
• 23. eikem 61 pts. 11,809
• 24. pauldunn 59 pts. 11,809
• 25. je4 58 pts. 11,798
• 26. vakobo 56 pts. 11,743
• 27. johnmitch 55 pts. 11,729
• 28. wisky 54 pts. 11,707
• 29. Flagg65a 52 pts. 11,696
• 30. bob1928 51 pts. 11,663

Comments

[bkoep]

We've tried to estimate the number of residues required to close each loop, but you may prefer to distribute these residues differently. You can delete residues from one loop and reinsert them into another, although you cannot add additional residues to this puzzle.

There is no RMSD filter for this puzzle, but there are some constraints to help keep the secondary structure pieces in place. Note also that you can wiggle the backbone of the Abeta peptide, although there are constraints to keep the two Abeta strands in a sheet.

[viosca]

In this design puzzle, is it a requirement that all the design residues are used?

Thanks,
Randy

[bkoep]

Please feel free to delete residues from this puzzle. In fact, shorter loops are generally more likely to fold up as predicted, however, longer proteins tend to score better in Foldit. If you have a solution you think is a good design but doesn't score as well because it has fewer residues, please share it with us using the Upload for Scientists button!

[bkoep]

The expiration date for this puzzle has been extended to Sunday, January 26 to accommodate the delayed release of the newchapter update.

[salish99]

My PC cannot handle this one. I barely loaded it, when it hangs. Works with all other puzzles, though…

[v_mulligan]

Have you updated to the latest version of the game client, salish99? The programmers had to fix a couple of little bugs in order to get the loop closure puzzles to work properly, so older versions of the game don't work properly with these puzzles.

If that's not the problem, could you leave a report in the "Feedback" section? The game programmers check that regularly, and can address this if it is a bug. Thank you!

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