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884b: 74 Residue Ebola Binder Design

Closed since almost 12 years ago

Intermediate Overall Design

Summary

Created
May 02, 2014
Expires
Max points
100
Description

NOTE: This puzzle replaces Puzzle 884, which had scoring and filter calibration issues. Players may load in solutions from the originally posted puzzle.

This is a design puzzle similar to Puzzle 879—now with 74 residues—near the interface of a target glycoprotein from the Ebola virus. At the binding site of the Ebola protein, there is already a helix designed by scientists in the Baker Lab, but the helix will not fold up by itself! Build a scaffold around the starting design that will fold up properly and stabilize the binding helix! There are strong constraints to keep the binding helix in place, and you may not mutate residues at the interface. You may not add additional residues to the design, but you may delete residues from one end of the design and reinsert them at the other end. This puzzle includes a Residue IE Score filter and a Core Existence filter, and High Wiggle Power has been disabled. Remember to share your favorite designs using the Share with Scientist tool, even if those are not your best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 12,928
  2. Avatar for Beta Folders 2. Beta Folders 84 pts. 12,905
  3. Avatar for Deleted group 3. Deleted group pts. 12,772
  4. Avatar for Contenders 4. Contenders 57 pts. 12,724
  5. Avatar for Void Crushers 5. Void Crushers 47 pts. 12,686
  6. Avatar for Deleted group 6. Deleted group pts. 12,585
  7. Avatar for Russian team 7. Russian team 30 pts. 12,569
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 24 pts. 12,548
  9. Avatar for Go Science 9. Go Science 19 pts. 12,517
  10. Avatar for Gargleblasters 10. Gargleblasters 15 pts. 12,476
  1. Avatar for froggs554 31. froggs554 Lv 1 47 pts. 12,503
  2. Avatar for Museka 32. Museka Lv 1 46 pts. 12,494
  3. Avatar for Bletchley Park 33. Bletchley Park Lv 1 45 pts. 12,493
  4. Avatar for NickyCGS 34. NickyCGS Lv 1 44 pts. 12,472
  5. Avatar for mimi 35. mimi Lv 1 42 pts. 12,462
  6. Avatar for BackupElk 36. BackupElk Lv 1 41 pts. 12,448
  7. Avatar for Hiro Protagonist 37. Hiro Protagonist Lv 1 40 pts. 12,447
  8. Avatar for g_b 38. g_b Lv 1 39 pts. 12,443
  9. Avatar for KarenCH 39. KarenCH Lv 1 38 pts. 12,437
  10. Avatar for karost 40. karost Lv 1 37 pts. 12,434

Comments

bkoep Staff Lv 1

This puzzle should score have a more reasonable Core Exists filter threshold, and should score much higher in general than the original puzzle.

Timo van der Laan Lv 1

If we are to get more Ebola puzzle, please make it so that the colouring of segments is only done to the segmentscores of the part we can influence (segments 186 and higher on this one).
Because of segments inside Ebola that score very badly we are not able to indentify bad scoring segment by visual means.