887: 70 Residue Monomer Design: Strand Constrained

Closed since almost 12 years ago

Summary

• Created: May 04, 2014
• Expires: May 11, 2014 at 23:00 UTC
• Max points: 100

Description

This is a single-chain design puzzle with 70 residues, and four of the residues are pre-folded into beta-strand conformation. These residues are somewhat flexible, but there are strong constraints to keep them close to beta-strand conformation. There are 3 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 25% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Anthropic Dreams 100 pts. 9,660
• 2. Contenders 82 pts. 9,552
• 3. Gargleblasters 66 pts. 9,525
• 4. Beta Folders 53 pts. 9,520
• 5. L'Alliance Francophone 42 pts. 9,498
• 6. Void Crushers 33 pts. 9,497
• 7. Go Science 26 pts. 9,446
• 8. SETI.Germany 20 pts. 9,339
• 9. Russian team 15 pts. 9,255
• 10. Deleted group pts. 9,232

Top soloists

• 31. grogar7 46 pts. 9,242
• 32. Vredeman 45 pts. 9,236
• 33. Anfinsen_slept_here 43 pts. 9,232
• 34. pvc78 42 pts. 9,214
• 35. Hiro Protagonist 41 pts. 9,204
• 36. O Seki To 40 pts. 9,199
• 37. smilingone 39 pts. 9,144
• 38. pauldunn 37 pts. 9,137
• 39. Znaika 36 pts. 9,136
• 40. NickyCGS 35 pts. 9,110