Placeholder image of a protein
Icon representing a puzzle

898b: 75 Residue Monomer Design: Weak Helices

Closed since almost 12 years ago

Intermediate Overall Design

Summary

Created
May 23, 2014
Expires
Max points
100
Description

NOTE: This is a repost of Puzzle 898, with the Fragment Filter removed.

This is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Russian team 11. Russian team 5 pts. 9,052
  2. Avatar for Deleted group 12. Deleted group pts. 8,965
  3. Avatar for Richard Dawkins Foundation 13. Richard Dawkins Foundation 2 pts. 8,840
  4. Avatar for HMT heritage 14. HMT heritage 2 pts. 8,834
  5. Avatar for Italiani Al Lavoro 15. Italiani Al Lavoro 1 pt. 8,543
  6. Avatar for Natural Abilities 16. Natural Abilities 1 pt. 8,496
  7. Avatar for Piratenpartei Deutschland 17. Piratenpartei Deutschland 1 pt. 8,445
  8. Avatar for Repro-men 18. Repro-men 1 pt. 8,392
  9. Avatar for Team Schleswig-Holstein 19. Team Schleswig-Holstein 1 pt. 8,217
  10. Avatar for Mojo Risin' 20. Mojo Risin' 1 pt. 8,101
  1. Avatar for eikem 21. eikem Lv 1 59 pts. 9,242
  2. Avatar for johnmitch 22. johnmitch Lv 1 58 pts. 9,238
  3. Avatar for drumpeter18yrs9yrs 23. drumpeter18yrs9yrs Lv 1 56 pts. 9,231
  4. Avatar for smholst 24. smholst Lv 1 55 pts. 9,228
  5. Avatar for BootsMcGraw 25. BootsMcGraw Lv 1 53 pts. 9,225
  6. Avatar for hpaege 26. hpaege Lv 1 52 pts. 9,201
  7. Avatar for frood66 27. frood66 Lv 1 50 pts. 9,159
  8. Avatar for Bautho 28. Bautho Lv 1 49 pts. 9,156
  9. Avatar for wisky 29. wisky Lv 1 47 pts. 9,137
  10. Avatar for Antibrad 30. Antibrad Lv 1 46 pts. 9,128

Comments

spmm Lv 1

I am not finding any difference between low and medium wiggle power on this one.

retiredmichael Lv 1

constraints still need work, had some computer issues, so was not able to fully work the sheet array's. you could just set some rules, the folds must contain 3-5 elements 2 of which must be sheets.