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898b: 75 Residue Monomer Design: Weak Helices

Closed since almost 12 years ago

Intermediate Overall Design

Summary

Created
May 23, 2014
Expires
Max points
100
Description

NOTE: This is a repost of Puzzle 898, with the Fragment Filter removed.

This is a design puzzle with 75 residues and is very similar to previous design puzzles, except that helices should not score as well as they normally do. Try some new designs and see how they compete with handicapped helices! There are 2 filters enabled on this puzzle: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well, and the Core Existence filter checks that at least 30% of the residues are buried in the core of your design. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

spmm Lv 1

I am not finding any difference between low and medium wiggle power on this one.

retiredmichael Lv 1

constraints still need work, had some computer issues, so was not able to fully work the sheet array's. you could just set some rules, the folds must contain 3-5 elements 2 of which must be sheets.