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955: 70 Residue Monomer Design

Closed since over 11 years ago

Summary

Created: July 31, 2014
Expires: August 06, 2014 at 23:00 UTC
Max points: 100

Description

This design puzzle uses a Secondary Structure filter similar to that of Puzzle 937. Players will receive a 500 point bonus if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. There are 3 additional filters: the Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 3 designs that you want us to look at, even if they are not the best-scoring solutions!