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972: 80 Residue Monomer Design: Pro Loops

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
August 21, 2014
Expires
Max points
100
Description

In this design puzzle, we're encouraging players to incorporate PRO residues in the loops of their designs, so PRO residues will score more favorably than normal. Players will receive a 500 point bonus from the Secondary Structure filter if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. The Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

wisky Lv 1

Would very much like to see a couple design puzzles along the road with 120 or even 150 residues :) I think it would give a lot more room for interesting designs like beta barrels and the like. Not saying every design from here on out should be large like that, but it would be cool to have a couple of them :)