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972: 80 Residue Monomer Design: Pro Loops

Closed since over 11 years ago

Intermediate Overall Design

Summary

Created
August 21, 2014
Expires
Max points
100
Description

In this design puzzle, we're encouraging players to incorporate PRO residues in the loops of their designs, so PRO residues will score more favorably than normal. Players will receive a 500 point bonus from the Secondary Structure filter if fewer than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices. The Residue IE Score monitors that all PHE, TYR, and TRP residues are scoring well; the Core Existence filter checks that at least 30% of the residues are buried in the core of your design; and the Fragment filter scans for parts of your design that are unlikely to fold up naturally. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for L'Alliance Francophone
    1. L'Alliance Francophone
    100 pts. 10,410
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 83 pts. 10,361
  3. Avatar for Beta Folders 3. Beta Folders 68 pts. 10,286
  4. Avatar for Deleted group 4. Deleted group pts. 10,235
  5. Avatar for Contenders 5. Contenders 44 pts. 10,068
  6. Avatar for Go Science 6. Go Science 35 pts. 10,037
  7. Avatar for Deleted group 7. Deleted group pts. 9,998
  8. Avatar for SETI.Germany 8. SETI.Germany 21 pts. 9,918
  9. Avatar for Void Crushers 9. Void Crushers 16 pts. 9,878
  10. Avatar for Gargleblasters 10. Gargleblasters 12 pts. 9,371
  1. Avatar for smilingone 51. smilingone Lv 1 30 pts. 9,186
  2. Avatar for bamh 52. bamh Lv 1 29 pts. 9,177
  3. Avatar for goastano 53. goastano Lv 1 28 pts. 9,170
  4. Avatar for justjustin 54. justjustin Lv 1 28 pts. 9,136
  5. Avatar for Grom 55. Grom Lv 1 27 pts. 9,135
  6. Avatar for Deleted player 56. Deleted player 26 pts. 9,108
  7. Avatar for joaniegirl 57. joaniegirl Lv 1 25 pts. 9,105
  8. Avatar for jobo0502 58. jobo0502 Lv 1 25 pts. 9,060
  9. Avatar for ManVsYard 59. ManVsYard Lv 1 24 pts. 9,053
  10. Avatar for silverberg 60. silverberg Lv 1 23 pts. 9,032

Comments

wisky Lv 1

Would very much like to see a couple design puzzles along the road with 120 or even 150 residues :) I think it would give a lot more room for interesting designs like beta barrels and the like. Not saying every design from here on out should be large like that, but it would be cool to have a couple of them :)