Placeholder image of a protein
Icon representing a puzzle

Beginner Puzzle (<150): Docking Design

Closed since over 11 years ago

Beginner Beginner

Summary

Created
January 27, 2014
Expires
Max points
100
Description

We are giving you a helix positioned over a hydrophobic groove where binding occurs in nature. You can mutate any residue on the helix but none on the native binding region. Try to look for favorable hydrophobic interactions in this groove while maintaining the helix. For players with fewer than 150 global points.



START HERE:

If you are new to Foldit, here are detailed instructions to get you started:

http://fold.it/portal/node/988864

_____________________________


If you want to fold proteins, know that there are many ways to play and this variety is the main value of Foldit :

- try all puzzles not only "Beginners" ones,

- fold first the ones you like the most,

- try it by yourself to understand what works and what doesn't,

- ask for tips in global chat when you think you don't understand something.


Make sure you have followed these tutorials:

- Lonely Sheets,

- Lock and Lower,

- Rebuild,

- Structure and Rebuild,

- Movin' Along,

- Control over Clashing,

- Intro to Design,

- Swappin' Sidechains,

- Mass Mutate,

- Insertion and Deletion


before starting this puzzle.

Top groups

  1. Avatar for FoldIt@Netherlands 21. FoldIt@Netherlands 2 pts. 8,901
  2. Avatar for NewWestCharterScienceRocks 22. NewWestCharterScienceRocks 1 pt. 8,863
  3. Avatar for DCC Folders 23. DCC Folders 1 pt. 8,846
  4. Avatar for Ms. Jacques Hon Bio 2014 24. Ms. Jacques Hon Bio 2014 1 pt. 8,843
  5. Avatar for Deleted group 25. Deleted group pts. 8,802
  6. Avatar for Waverki 26. Waverki 1 pt. 8,786
  7. Avatar for USD_IMB_2014 27. USD_IMB_2014 1 pt. 8,766
  8. Avatar for foldeRNA 28. foldeRNA 1 pt. 8,751
  9. Avatar for Mrs Fretz CP Biology 2014 29. Mrs Fretz CP Biology 2014 1 pt. 8,662
  10. Avatar for UTEP Clinical Chemistry 2014 30. UTEP Clinical Chemistry 2014 1 pt. 8,536
  1. Avatar for astrozheng 51. astrozheng Lv 1 82 pts. 9,186
  2. Avatar for Tha5020thm 52. Tha5020thm Lv 1 81 pts. 9,185
  3. Avatar for Deleted player 53. Deleted player pts. 9,185
  4. Avatar for TRACKTOR97 54. TRACKTOR97 Lv 1 81 pts. 9,184
  5. Avatar for pfrasse 55. pfrasse Lv 1 80 pts. 9,184
  6. Avatar for kytyn 56. kytyn Lv 1 80 pts. 9,183
  7. Avatar for skhgsb 57. skhgsb Lv 1 80 pts. 9,183
  8. Avatar for poaceae 58. poaceae Lv 1 79 pts. 9,181
  9. Avatar for rjeachus 59. rjeachus Lv 1 79 pts. 9,181
  10. Avatar for MoonwalkingBear 60. MoonwalkingBear Lv 1 79 pts. 9,181

Comments

rjsthethird Lv 1

Is it just me or did the scoring on this change when the program was last updated? I had a score of 9148 saved, but when I opened it the score came in at 8818.

upquark1 Lv 1

Same here. My score was 9,196 a couple days ago. Now I can't get back for the life of me. My best is now 8,928.7

jstoddard Lv 1

Does the fragment have to be a helix? The instructions suggested that any amino acid could be mutated on the helix. I didn't think to try explore alternate loops until a couple days ago.