New puzzles posted in devprev

Started by beta_helix

beta_helix Staff Lv 1

Since CASP is monopolizing the available puzzle spots, we'll be posting some non-CASP puzzles to try out (available in the Foldit Developer Preview, see below) in case you want a change of scenery (or a preview of what is to come).

The first such puzzle has just been posted, it's called "Flu Puzzle Testing" and will probably be the first non-CASP puzzle to be released once we have an opening in the puzzle queue.

These puzzles will not be scored and your solutions will not be analyzed.
I will add to this post anytime a new puzzle is added.

Q: How do I try out the Foldit Developer Preview?
A: Locate your Foldit data directory (see next question). Open the file options.txt and change the update_group variable from "main" to "devprev".

Q: Where can I find the Foldit data files?
A: The data files are in different places depending on your OS:

on Windows:
    if you installed after 8/23/2011, they will be in your installation directory (the default is C:\Program Files\Foldit\ or C:\Program Files (x86)\Foldit\)
    if you installed prior to 8/23/2011:
        on Windows XP at C:\Documents and Settings\All Users\Application Data\Foldit\
        on Windows 7 and Vista at C:\ProgramData\Foldit\
on a Mac, Ctrl-click on the app and choose "Show Package Contents, then go to Contents/Resources
on Linux, is is the Foldit directory

Q: I've had enough of the preview! How do I go back?
A: In your options.txt file (see first question), just change your update_group variable back to "main" from "devprev".

beta_helix Staff Lv 1

Tissue Regeneration Puzzle

A different version of it will hopefully be posted soon (for everyone who is getting a bit sick of CASP puzzles).

jflat06 Staff Lv 1

We've run this puzzle before.

Previously, the two locked regions were cut apart from rest of the protein and secured with constraints. This was because we want to keep this region essentially the same.

I've added functionality to let us place constraints across the symmetric interface. Now, instead of using cuts, we've just locked both regions, and put strong constraints securing the two locked regions together in that conformation.

It should now be technically possible to move them, but it should be very hard, and score poorly. If you're able to modify the relative position of the two locked regions significantly, and still score well, this is a problem, and we'll want to know about it.

beta_helix Staff Lv 1

We have reposted Puzzle 571: Tissue Regeneration Design Puzzle, this time with a new patch designed to help with scoring artifacts.
The Puzzle is in devprev and called: residueIE filter test

Many players had pointed out that saturating the helix with aromatics was leading to high scores, but unrealistic structures:
http://fold.it/portal/node/992879#comment-18149
&
http://fold.it/portal/node/992544
&
http://fold.it/portal/node/992899

We have added a patch to the identical puzzle in hope that this will help with the problem.

Please let us know your thoughts, thank you for your help and patience with this!