Placeholder image of a protein
Icon representing a puzzle

1062: 85 Residue Monomer Design: Zero Cysteines

Closed since almost 11 years ago

Intermediate Overall Design

Summary


Created
March 10, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Anthropic Dreams 100 pts. 10,591
  2. Avatar for Contenders 2. Contenders 83 pts. 10,504
  3. Avatar for Beta Folders 3. Beta Folders 68 pts. 10,483
  4. Avatar for L'Alliance Francophone 4. L'Alliance Francophone 55 pts. 10,474
  5. Avatar for Void Crushers 5. Void Crushers 44 pts. 10,418
  6. Avatar for Go Science 6. Go Science 35 pts. 10,348
  7. Avatar for Herobrine's Army 7. Herobrine's Army 27 pts. 10,325
  8. Avatar for Gargleblasters 8. Gargleblasters 21 pts. 10,302
  9. Avatar for Deleted group 9. Deleted group pts. 10,197
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 12 pts. 9,898

  1. Avatar for doogong 211. doogong Lv 1 1 pt. 0
  2. Avatar for Loek 212. Loek Lv 1 1 pt. 0
  3. Avatar for MadTrumpeter 213. MadTrumpeter Lv 1 1 pt. 0
  4. Avatar for cjoseph 214. cjoseph Lv 1 1 pt. 0
  5. Avatar for Johnrqrqrq 215. Johnrqrqrq Lv 1 1 pt. 0
  6. Avatar for shinyarceus4 216. shinyarceus4 Lv 1 1 pt. 0
  7. Avatar for Dantoto 217. Dantoto Lv 1 1 pt. 0
  8. Avatar for aspadistra 218. aspadistra Lv 1 1 pt. 0
  9. Avatar for xherox55 219. xherox55 Lv 1 1 pt. 0
  10. Avatar for inkycatz 220. inkycatz Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.