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1062: 85 Residue Monomer Design: Zero Cysteines

Closed since about 11 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design

Summary


Created
March 10, 2015
Expires
Max points
100
Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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  1. Avatar for jflat06 222. jflat06 Lv 1 1 pt. 0
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  3. Avatar for eszerfrm 224. eszerfrm Lv 1 1 pt. 0
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  5. Avatar for Schleicher 226. Schleicher Lv 1 1 pt. 0
  6. Avatar for Antibrad 227. Antibrad Lv 1 1 pt. 0
  7. Avatar for packer 228. packer Lv 1 1 pt. 0
  8. Avatar for decbin 229. decbin Lv 1 1 pt. 0
  9. Avatar for Dantoto 230. Dantoto Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.