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1065: 90 Residue Monomer Design: Zero Cysteines

Closed since almost 11 years ago

Summary

Created: March 18, 2015
Expires: March 26, 2015 at 07:00 UTC
Max points: 100

Description

In this puzzle, we're asking players to design a protein with no cysteine residues! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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1. MurloW Lv 1
100 pts. 10,787
2. retiredmichael Lv 1 98 pts. 10,748
3. eusair Lv 1 96 pts. 10,730
4. dembones Lv 1 94 pts. 10,683
5. karstenw Lv 1 92 pts. 10,679
6. santex Lv 1 90 pts. 10,653
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9. g_b Lv 1 84 pts. 10,623
10. nicobul Lv 1 82 pts. 10,616

Comments

bkoep Staff Lv 1

March 18, 2015

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Fragment Score: Scans for parts of your design that are unlikely to fold up naturally. Use Rebuild and Remix tools to fix these regions of your design!

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets. Also penalizes hydrophilic residues in the core and hydrophobic residues on the surface.